Magruder is the main antagonist of the story. He is voiced by Lance Henriksen.
Thomas Magruder is a one-eyed railroad tycoon. He last his eye in a lone shot fired by Colton White's mother. He is the main enemy of Colton White and was the one who murdered his mother. He has two men who follow his command, Reed and Dutchie. He is on a mission to find the lost city of gold Quivera, he has been on that misson since the civil war. During the war he was a confederate major and led a group of soldiers, which included Clay Allison and Ned White, to find Quivera.
At the end of the game he finds Quivera and engages in a firefight with Cole. The mountain caves in and crushes Magruder while Cole excapes.